Scientists develop novel nanoparticles that could serve as contrast agents

The researchers developed what are known as single-chain nanoparticles (SCNPs) which are made up of a single molecular chain and are only three to five nanometres in size. Dyes can be incorporated in these tiny capsules. "Our SCNPs have unique thermoresponsive properties as their structure changes when exposed to heat. Depending on the temperature, the particles can take on a compact or open structure. The behaviour of the encapsulated substances also changes," explains chemist Professor Wolfgang Binder from MLU, who led the study together with medical physics professor Jan Laufer, and pharmacist Karsten Mäder. 

For the study, the team incorporated special dyes into the SNCPs which could then be used in photoacoustic imaging. In this type of method, laser pulses are directed at the tissue being examined. There, the energy of the light is converted into ultrasound waves, the tissue heats up, and the properties of the nanoparticles change. When the ultrasound waves are measured outside the organism, three-dimensional images can be created that mostly show blood vessel networks. According to the researchers, the particles create a rich optical contrast that can be used, for example, to examine tumours more closely. 

The team also studied how the particles functioned in cell cultures so that they could better understand if and how they work in the human body. This is crucial if the particles are to be used in biomedical applications. The novel particles performed very well in all of the tests they underwent. "Our work is an important step in the development of thermoresponsive SCNPs, which could improve the accuracy and precision of diagnostic imaging," Binder concludes. 

The study was funded by the German Research Foundation.

Study: Thümmler J.F. et al. Thermoresponsive Swelling of Photoacoustic Single-Chain Nanoparticles. Chemical Communications (2023). doi: 10.1039/D3CC03851C

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